In addition to bioanalysis of small molecule drugs in plasma, at Pine Lake Laboratories we also have extensive experience developing bioanalytical methods by LC-MS/MS for drugs in tissue and other biological matrices.    In general, tissues present a more complicated matrix than biological fluids but a well-designed mixed mode solid phase extraction method can usually handle the additional challenges of biological tissues.   Below are examples of biological fluid and tissue matrices in which we have successfully developed methods:

• Plasma, blood, serum, synovial fluid, urine, feces and vaginal fluid
• Tissues: Liver, kidney, spleen, brain, spinal cord, heart, eye, muscle, dermis and vaginal

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